What are Complex Disorders?
Complex Disorders chronic illnesses that often follow infections, trauma, or biological stressors. Unlike traditional medical models, these conditions are multi-systemic and require a new path to diagnosis and treatment. These conditions don't just affect one organ; they disrupt multiple systems - including the immune, nervous, structural, and gastrointestinal systems.
This is why they are also called “Neuroimmune Disorders”.
And there’s no clear path to diagnosis or treatment. That’s why CODA is here - to fuel research and bring answers to the millions of patients who need them.
Diagnoses of Complex Disorders Include:
Long COVID
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Dysautonomia
Positional Tachycardia Syndrome (POTS)
Ehlers Danlos Syndrome (EDS)
Hypermobile Spectrum Disorder (HSD)
Hypermobile Spectrum Disorder (HSD)
Mast Cell Activation Syndrome (MCAS)
Chronic Pain Regional Syndrome (CRPS)
Sjögren’s
Fibromyalgia
Post Acute Lyme Disease
Chronic Migraine
Fibromyalgia
Gastroparesis
Irritable Bowl Syndrome (IBS)
Inflammatory Bowel Disease (IBD)
Endometriosis
and more!
Why is CODA Studying Neuroimmune Science?
Provides a unifying biological framework
Examines the neuroimmune signaling and crosstalk
One of the fastest-growing fields in biomedicine (300% publication growth in 10 years)
Connects cross-disease studies into one coordinated program
FAQs
Why is CODA researching the overlap of complex disorders?
1
Many complex disorders may share common biological pathways, including immune dysfunction, inflammation, autonomic dysregulation, and metabolic disruption. Patients often experience overlapping symptoms and multiple diagnoses, suggesting shared underlying mechanisms.
Researching these overlaps helps identify common drivers of disease, improve diagnostic accuracy, and accelerate the development of more targeted and effective treatments.
What percent of complex disorders affect females?
2
85% of females living with complex, chronic disorders are women - yet the reasons behind this remain under-researched and poor misunderstood. CODA is motivated to fuel research initiatives that study women’s health.
Why do Complex Disorders appear across multiple specialties?
3
Complex disorders often affect more than one biological system at the same time, including the immune, nervous, endocrine, and gastrointestinal systems. Because medicine is organized by specialty and organ system, patients with multi-system conditions frequently see multiple providers.
When underlying biological pathways such as inflammation or neuroimmune signaling become dysregulated, symptoms can appear diverse and seemingly unrelated. Advancing research that integrates across disciplines is essential to better understanding and treating these conditions.