Patients with complex disorders need solutions. We’re finding them.

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Millions of people are living with complex disorders.

These disorders don’t affect just one organ. They don’t follow a single pattern.

Complex disorders are chronic conditions that disrupt multiple systems in the body—immune, nervous, structural, and gastrointestinal.

These disorders disproportionately affect women—more often and more severely. Yet science has yet to fully understand why.

They’re often triggered or worsened by infections, trauma, surgery, or other biological stressors. Most are misunderstood. Nearly all are missing from today’s medical model.

And there’s no clear path to diagnosis or treatment.

  • 400+ Million

    Long COVID patients worldwide

  • 75%—85%

    Of individuals diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) are women

  • 70 Million

    People estimated worldwide affected by autonomic dysfunction, also known as dysautonomia

  • 2X

    Women are almost twice as likely as males to be diagnosed with an autoimmune disease

  • 1.1 Billion

    Individuals globally are estimated to suffer from migraines

  • 42%

    Of the U.S. population have 2+ chronic conditions

  • 190 Million

    Endometriosis affects roughly 10% of reproductive age women globally

  • 1:15 Individuals

    In the U.S. has an autoimmune disease

They include, but aren’t limited to:
Long COVID, ME/CFS, POTS/Dysautonomia, Chronic Migraine, Sjögren’s, EDS/HSD, MCAS, CRPS, Fibromyalgia, Endometriosis, Gastroparesis, Food Allergy, IBS, IBD

What connects these conditions isn’t just symptoms—it’s biology. They present in ways medicine isn’t built to recognize, leaving patients without clear diagnoses or proven therapies.

CODA is working to connect the dots, uncover shared mechanisms, and find new and effective treatments.

The overlap is clear. The reason is not.
Together, We Can Change That.

The CODA Catalyst

A problem this big demands a bold, transformative system to drive breakthroughs.

When science, data, and urgency align, diseases are cured. We’re applying a proven system to complex disorders.

Infographic with concentric circles and a central theme "accelerate cures." Steps: 1. Start with the patient, 2. Collect the right data, 3. Analyze the data deeply, 4. Engage the right experts, 5. Turn insights into action.

  • Grounding everything in lived experience, unmet need, and what success looks like for the people we serve.

  • From patients, biobanks, clinical records, and lived experience—to build a foundation that reflects real-world complexity.

  • Uncover biomarkers, decode disease mechanisms, and launch major studies that lead to clinical trials, drug repurposing, and new therapies.

  • Connecting researchers and clinicians to the questions that matter, and the data that can drive answers.

  • Delivering usable knowledge directly to doctors and patients at the point of care.

The CODA Alliance

Bringing answers to patients faster starts a best-in-class research network built for speed and collaboration.

For too long, science has been fragmented—slowing the breakthroughs patients urgently need. At CODA, we’re breaking down those barriers with a powerful research network that brings together changemakers across fields to solve the complex problems siloed science has left unanswered.

Diagram with 'coda' in the center surrounded by connected nodes labeled government, biopharma, patients, biotech, foundations, academic centers, and scientists.

Where Medicine Stops, CODA Starts

“Sometimes a diagnosis isn’t terminal, but it also isn’t curable. There is an ugly crevasse where millions of us are existing between the shadows of the actively dying and healthy living, hoping someday relief from debilitating symptoms will find us. CODA has boldly opted to focus on supporting research that will help patients with these often forgotten, but common conditions and is the reason I remain hopeful that someday I will return to a life where my body no longer struggles to thrive.”

— Summer Dashe, Patient, Advocate, Journalist

Summer Dashe smiling, wearing a pink shirt with 'POTS girl Summer' text, standing outside near a stone wall.