Our Research

CODA’s 5 Neuroimmune Research Domains: An Integrated Framework for Diagnosis and Treatment

CODA advances a coordinated set of programs across five interconnected neuroimmune domains to define patient subtypes and guide targeted treatment strategies. CODA’s flagship programs span multiple domains and are shown within each domain to illustrate how these systems interact in the same patient.

Microscopic view of nerve cells and surrounding tissue stained in purple.

Neuroimmune Signaling

Reciprocal feedback loops between the autonomic nervous system and the immune system are increasingly recognized as central to homeostasis. Disruptions in these neuroimmune circuits, whether originating in the immune or neural systems, may drive complex chronic illness.

    • CODA Craniocervical Dysfunction (CCD) Initiative

    • General Vagus Nerve Stimulation – SetPoint (Dr. Kevin Tracey)

Studies and Initiatives

Close-up illustration of neurons with electrical signals.

Immune Network Dysregulation

The immune system can shift into a persistently activated yet poorly regulated state, with altered signaling across immune pathways. This can drive ongoing inflammation, disrupt coordinated immune function, and limit the system’s ability to resolve activation and return to baseline.

    • CODA Craniocervical Dysfunction (CCD) Initiative

    • ANKTIVA / Inspiritol (Dr. Nancy Klimas, Dr. Patrick Soon-Shiong)

    • Regulatory T-cell / T-reg Pathways (Dr. Diane Mathis, Dr. Miguel Marin-Rodero)

Studies and Initiatives

Close-up computerized image of a coronavirus particle with spike proteins protruding from its surface, colored in shades of orange, green, and blue.

Viral and Microbial Persistence

Residual viral or microbial components may persist within tissues or protected biological compartments, continuing to engage immune recognition pathways. This ongoing signaling can sustain innate immune activation and reinforce downstream neural and inflammatory responses.

    • CODA Craniocervical Dysfunction (CCD) Initiative

    • Monoclonal Antibodies

    • Microclotting Program (Dr. Resia Pretorius, Dr. Douglas Kell)

Studies and Initiatives

A medical image showing a series of brain scans, likely MRI or CT images, displayed on a lightbox.

CSF, Glymphatics, Cerebral & Venous Blood Flow

Alterations in cerebrospinal fluid movement, glymphatic function, and cerebral and venous blood flow can shift pressure dynamics and impair metabolic exchange. These disruptions can reduce support for neural tissue and destabilize coordinated signaling across brain systems.

    • CODA Craniocervical Dysfunction (CCD) Initiative

    • Glymphatics Study (Jonathan Kipnis, WashU)

Studies and Initiatives

An X-ray image of a human figure standing with arms outstretched, showing bones and skeletal structure against a black background.

Structural Mechanics & Instability

Changes in connective tissue integrity can affect how mechanical forces are distributed across the body. This can influence joint stability, alter sensory input, and impact the consistency of signaling across neural and vascular structures.

    • CODA Craniocervical Dysfunction (CCD) Initiative

Studies and Initiatives

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