It’s About Time.
Research that Moves the Needle.

Because patients can’t wait—and neither will we.

We can’t move fast enough because patients have already waited years - even decades - for help. From biomarker discovery to clinical trial design, we focus on the science that can directly improve how complex conditions are diagnosed, treated, and understood.

Our Research Framework: Neuroimmune Science

Complex disorders don’t happen in isolation—and neither should research.

Everything we do at CODA is designed to bring together the people, data, and disciplines needed to drive real progress—and that starts with how we study the biology of these conditions.

Our interdisciplinary approach—powered by best-in-class scientists and real-world data—lets us uncover mechanisms of disease, measure what’s working for patients, and accelerate treatment strategies that go beyond symptom management.

CODA is laser-focused on building and supporting vital neuroimmune studies, partnerships and projects that intersect, yield critical data and inform one another. We don’t simply fund small studies - we establish major partnerships to make a larger impact. 

  • Blue DNA helix icon on a white background.

    Biomarker Discovery

    By analyzing data from multiple biological systems - genes, proteins, cells, and more - we’re building a clearer picture of what drives complex conditions to identify biomarkers, improve diagnoses, and guide more personalized treatment strategies.

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    Neuroscience

    Neuroscience research looks at how problems in the nervous system can lead to symptoms such as chronic pain, fatigue, and issues with heart rate or digestion. By understanding how the brain and body communicate, we can find better ways to treat the underlying causes of these conditions.

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    Immune Dysfunction

    Many chronic illnesses involve problems with the immune system, but what sets it off—and how it stays activated—isn’t always clear. By studying these immune triggers and responses, we can find better ways to treat the real cause, not just the symptoms.

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    Structural Mechanics

    Connective tissue, mobility, and mechanical stability all play a role in complex disorders—but are often overlooked. We investigate how physical structure affects biological function to better understand symptom drivers and treatment opportunities.

Together, these areas form the foundation of our work—and our path toward real answers.

Together, these areas form the foundation of our work—and our path toward real answers.

Scientist wearing protective eyewear and gloves, operating laboratory equipment with test tubes in a lab.

CODA Neuroimmune Research Project:

Multiple neuroimmune programs and studies are underway or in active development.

And we can’t move forward without your participation and support. These studies only happen with patient engagement and funding. Please donate to power the science patients are waiting for.

  • Craniocervical dysfunction is often reported by patients with complex multisystem disorders, yet it remains under-investigated and inconsistently addressed in both research and clinical practice, leaving patients with few to no evidence-based interventions. 

    The underlying mechanisms remain unknown, but what we do know is that the cervical region is central to stability, blood and cerebrospinal fluid flow, vestibular balance, autonomic regulation, immune activity, and more. 

    CODA CCI is a central initiative within the CODA Neuroimmune Research Project and a first-of-its-kind overarching research program, taking a human model approach and uniting large and small studies under one interconnected umbrella.

    CODA CCI investigates altered neuroimmune signaling at the craniocervical junction contributes to the initiation and progression of complex disorders.

    Structural factors in this region may heighten these neuroimmune shifts.

    CODA CCI offers a unique human model for studying and understanding the following interconnected areas:

    • Neuroimmune and inflammatory response

    • CSF & glymphatic flow

    • Cerebral and venous flow

    • Autonomic and vagal signaling

    • Structural Instability and compression

    • Musculoskeletal & neuromuscular control

  • CODA invests in multiomics studies and AI data analysis to have the data and tools to better understand which patients respond to which therapies: the backbone of precision medicine.

    Therapies only succeed when we understand who may respond and why. CODA subtyping studies investigate biological differences across patients to better understand who may respond to specific treatments. 

  • Breakthroughs happen when the best minds work together. Advancing this field requires bringing leading scientific labs into the work and creating real incentives for collaboration. Supporting fellows is one of the most effective ways to attract top talent, expand expertise, and keep research centered on the needs of patients.

    CODA supports junior and senior fellows at leading medical institutions to ensure science remains centered on patients.

  • CODA consistently accepts proposals that examine the most important areas of neuroimmune science. To inquire, please email info@complexdisorders.org.

CODA Publications

Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries

Published: 08 May 2025

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