It’s About Time.
Research that Moves the Needle.
Because patients can’t wait—and neither will we.
We can’t move fast enough because patients have already waited years - even decades - for help.
From biomarker discovery to clinical trial design, we focus on the science that can directly improve how complex conditions are diagnosed, treated, and understood.
Four Areas, One Goal: Understanding the Whole Patient
Complex disorders don’t happen in isolation—and neither should research.
Everything we do at CODA is designed to bring together the people, data, and disciplines needed to drive real progress—and that starts with how we study the biology of these conditions.
Our interdisciplinary approach—powered by best-in-class scientists and real-world data—lets us uncover mechanisms of disease, measure what’s working for patients, and accelerate treatment strategies that go beyond symptom management.
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Biomarker Discovery
By analyzing data from multiple biological systems - genes, proteins, cells, and more - we’re building a clearer picture of what drives complex conditions to identify biomarkers, improve diagnoses, and guide more personalized treatment strategies.
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Neuroscience
Neuroscience research looks at how problems in the nervous system can lead to symptoms such as chronic pain, fatigue, and issues with heart rate or digestion. By understanding how the brain and body communicate, we can find better ways to treat the underlying causes of these conditions.
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Immune Dysfunction
Many chronic illnesses involve problems with the immune system, but what sets it off—and how it stays activated—isn’t always clear. By studying these immune triggers and responses, we can find better ways to treat the real cause, not just the symptoms.
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Structural Mechanics
Connective tissue, mobility, and mechanical stability all play a role in complex disorders—but are often overlooked. We investigate how physical structure affects biological function to better understand symptom drivers and treatment opportunities.
Together, these areas form the foundation of our work—and our path toward real answers.
Together, these areas form the foundation of our work—and our path toward real answers.
The CODA Studies
Multiple major studies are already underway or in active development.
And we can’t move forward without your participation and support. These studies only happen with patient engagement and funding. Please donate to power the science patients are waiting for.
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MetX – Our large-scale data aggregation and biobanking initiative, built to connect insights across studies and unlock new disease mechanisms.
MeLo – A genomic and combinatorial study in partnership with PrecisionLife, focused on ME/CFS and Long COVID—using advanced algorithms to identify risk, prevalence, and therapeutic targets.Immune Profiling & Proteomics – Deep analysis of immune system behavior and protein expression to identify biomarkers and understand disease drivers.
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POTS & Autoimmunity – Investigating autoimmune contributions to postural orthostatic tachycardia syndrome (POTS) and developing diagnostic strategies.
MCAS & the Peripheral Nervous System – Studying how mast cell activation impacts the neuroimmune interface, and what it could mean for treatment.
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Diagnostics and Therapeutics – We’re designing and supporting trials that bring better tools to patients and doctors—from understanding which existing treatments work for which patients, to pushing forward new tests and therapies that could change what’s possible.
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CCI Study – A first-of-its-kind look at craniocervical instability (CCI) and its role in complex neuroimmune conditions. This landmark study will examine how cervicogenic function might drive neurological, autonomic, and immune dysfunction—opening new doors for diagnostics and care.