Our Research

Improving Care Through Neuroimmune Science

Complex disorders don’t happen in isolation and neither does our research.

At CODA, our research is built on the understanding that multi-system disorders require a multi-system lens. We need to look at the entire patient, understand their biology and find the right treatments for each individual. With that in mind, we examined the research landscape to identify 5 core biological areas that impact patients. We identified the best scientists working in each of these areas. We are now launching studies focused on treatments and improving patient outcomes.

To lern more about CODA’s neuroimmune research landscape and the studies we are funding explore our research page below.

  • Outline drawing of a human brain in blue.

    Neuroimmune Signaling

    How the nervous and immune systems, communicate, amplify symptoms and contribute to disease patterns

  • Blue DNA helix icon on a white background.

    Immune Network Dysregulation

    The immune system can shift into a persistently activated yet poorly regulated state, with altered signaling across immune pathways. This can drive ongoing inflammation, disrupt coordinated immune function, and limit the system’s ability to resolve activation and return to baseline.

  • Blue abstract geometric snowflake illustration.

    Viral & Microbial Persistence

    Residual viral or microbial components may persist within tissues or protected biological compartments, continuing to engage immune recognition pathways. This ongoing signaling can sustain innate immune activation and reinforce downstream neural and inflammatory responses.

  • A hand holding a test tube with molecular structures around it, representing science or chemistry.

    CSF, Glymphatics, Cerebral & Venous Blood Flow

    Alterations in cerebrospinal fluid movement, glymphatic function, and cerebral and venous blood flow can shift pressure dynamics and impair metabolic exchange. These disruptions can reduce support for neural tissue and destabilize coordinated signaling across brain systems.

  • Icon of a human figure surrounded by arrows pointing outwards.

    Structural Mechanics & Instability

    Changes in connective tissue integrity can affect how mechanical forces are distributed across the body. This can influence joint stability, alter sensory input, and impact the consistency of signaling across neural and vascular structures.

Together, these areas form the foundation of our work—and our path toward real answers.

Together, these areas form the foundation of our work—and our path toward real answers.

From Hypothesis to Discovery

Studies Across Five Research Areas Seeking Support

Radioactive symbol on a textured surface with scattered small black dots.

Neuroimmune Signaling

  • CODA CCD Initiative (Hyperlink to CODA CCD Page)

  • General Vagus Nerve Stimulation - Setpoint with Dr. Kevin Tracey, MD

X-ray image of a human figure with arms extended outward, displaying skeletal structure including skull, spine, ribs, and limbs.

Structural Mechanics & Instability

  • CODA CCD Initiative

  • MAESTRO Study with MIT

Close-up of a blue-purple sea urchin with long spines against a dark background.

Immune Network Dysregulation

  • CODA CCD Initiative

  • ANKTIVA/Inspiritol Study with Dr. Nancy Klimas and Dr. Patrick Soon-Shiong

  • Reglutory T-Cell / T Reg Pathways with Dr. Diane Mathius, PhD and Dr. Miguel Marin-Rodero, PhD

A black and white photo showing multiple brain scan images, arranged in a grid, likely from a CT or MRI scan.

CSF, Glymphatics, Cerebral & Venous Blood Flow

  • CODA CCD Initiative

  • Glymphatics Study with neuroimmune expert Jonathan Kipnis, Wash U.

Close-up black and white illustration of a virus particle with surface proteins

Viral and Microbial Persistence

  • CODA CCD Initiative

  • Monoclonal Antibodies

  • Microclotting Major Program with Dr. Resa Pretorius, PhD and Dr. Douglas Kell, PhD

A scientist wearing blue gloves holding a syringe with a vial inside a laboratory, with test tubes and medication packages on a metal surface.

Learn More

  • CODA drives neuroimmune research across biomarker discovery, neuroscience, immune dysfunction, and structural mechanics — bringing together leading researchers and real-world patient data to improve how complex conditions are diagnosed and treated.

    See the science in action.

  • Explore our latest publications here

We can’t move forward without you. Patient participation and generous support make our research possible

Donate to power the science patients are waiting for.

Donate To Fuel Research

From Hypothesis to Discovery:

Studies Across Five Research Areas Seeking Support

A neural cell with extensions and small dots around it.
A close-up of a sea urchin with a dark background, showing its spines illuminated in blue and purple hues.
Close-up of a coronavirus particle with spike proteins.
A series of black and white brain scan images displayed on a lightbox, showing different cross-sections of the brain from various angles.
Digital illustration of a human skeleton in a neutral pose, with arms extended horizontally, set against a black background.

Neuroimmune Signaling

Immune Network Dysregulation

  • CODA CCD Initiative (Hyperlink to CODA CCD Page)

  • General Vagus Nerve Stimulation - Setpoint with Dr. Kevin Tracey, MD

  • CODA CCD Initiative

  • ANKTIVA/Inspiritol Study with Dr. Nancy Klimas and Dr. Patrick Soon-Shiong

  • Reglutory T-Cell / T Reg Pathways with Dr. Diane Mathius, PhD and Dr. Miguel Marin-Rodero, PhD

Viral and Microbial Persistence

  • CODA CCD Initiative

  • Monoclonal Antibodies

  • Microclotting Major Program with Dr. Resa Pretorius, PhD and Dr. Douglas Kell, PhD

CSF, Glymphatics, Cerebral & Venous Blood Flow

  • CODA CCD Initiative

  • Glymphatics Study with neuroimmune expert Jonathan Kipnis, Wash U.

Structural Mechanics & Instability

  • CODA CCD Initiative

  • MAESTRO Study with MIT

We can’t move forward without your participation and support. These studies only happen with patient engagement and funding.

Please donate to power the science patients are waiting for.

Donate To Fuel Research

From Hypothesis to Discovery:

Studies Across Five Research Areas Seeking Support

CODA CCD Initative

Immune Network Dysregulation

  • CODA CCD Initiative (Hyperlink to CODA CCD Page)

  • General Vagus Nerve Stimulation - Setpoint with Dr. Kevin Tracey, MD

  • CODA CCD Initiative

  • ANKTIVA/Inspiritol Study with Dr. Nancy Klimas and Dr. Patrick Soon-Shiong

  • Reglutory T-Cell / T Reg Pathways with Dr. Diane Mathius, PhD and Dr. Miguel Marin-Rodero, PhD

Viral and Microbial Persistence

  • CODA CCD Initiative

  • Monoclonal Antibodies

  • Microclotting Major Program with Dr. Resa Pretorius, PhD and Dr. Douglas Kell, PhD

CSF, Glymphatics, Cerebral & Venous Blood Flow

  • CODA CCD Initiative

  • Glymphatics Study with neuroimmune expert Jonathan Kipnis, Wash U.

Structural Mechanics & Instability

  • CODA CCD Initiative

  • MAESTRO Study with MIT

We can’t move forward without your participation and support. These studies only happen with patient engagement and funding.

Please donate to power the science patients are waiting for.

Donate To Fuel Research

Multiple Neuroimmune Programs and Studies are Underway and Seeking Funding.

Subtyping Studies Reveal Distinct Patient Profiles to Drive Targeted Research

  • Seeking Funding.

    CODA CCD investigates altered neuroimmune signaling at the craniocervical junction contributes to the initiation and progression of complex disorders. Structural factors in this region may heighten these neuroimmune shifts. This initiative offers a unique human model for studying and understanding CODA’s five core research areas.

    Learn More About CODA CCD

  • The MIT MAESTRO Study, led by the Tal Research Group at Massachusetts Institute of Technology, is one of the most comprehensive clinical efforts to understand why some individuals recover from infection while others develop chronic illness.

    By collecting biological, cognitive, and physiological data across conditions like Lyme disease and Long COVID, the study aims to identify biomarkers, map illness trajectories, and uncover the underlying mechanisms driving chronic symptoms.

    This research has the potential to transform how complex conditions are diagnosed, understood, and treated - bringing us closer to predictive diagnostics and targeted therapies for patients.

    Learn More About the MAESTRO Study

  • Funded and In Progress.

    CODA is a proud funding partner of Sequence ME and Long Covid, the world's largest long-read, whole-genome sequencing study of any disease. Led by Action for ME in partnership with the University of Edinburgh and Oxford Nanopore Technologies, this study will analyze the complete genetic code of 9,000 people with ME and 9,000 people with Long Covid to identify rare and structural genetic changes that may underlie these conditions.

    Learn More About Sequence ME & Long COVID

  • Funded and Completed.

    CODA partnered with Chronicle Bio and PrecisionLife to launch the MELO Study, focused on identifying biomarkers linked to Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. These insights help uncover underlying biology, risk factors, and symptom drivers, highlighting key areas for deeper investigation.

    Returning results to participants was a core priority, offering meaningful insight into the research process and the impact of patient participation. This work has the potential to advance targeted studies, improve diagnostics, and accelerate the development of effective treatments.

    Learn More About the Melo Study

Scientist wearing protective eyewear and gloves, operating laboratory equipment with test tubes in a lab.

Multiple Neuroimmune Programs and Studies are Underway and Seeking Funding.

Subtyping Studies Reveal Distinct Patient Profiles to Drive Targeted Research

  • Seeking Funding.

    CODA CCD investigates altered neuroimmune signaling at the craniocervical junction contributes to the initiation and progression of complex disorders. Structural factors in this region may heighten these neuroimmune shifts. This initiative offers a unique human model for studying and understanding CODA’s five core research areas.

    Learn More About CODA CCD

  • The MIT MAESTRO Study, led by the Tal Research Group at Massachusetts Institute of Technology, is one of the most comprehensive clinical efforts to understand why some individuals recover from infection while others develop chronic illness.

    By collecting biological, cognitive, and physiological data across conditions like Lyme disease and Long COVID, the study aims to identify biomarkers, map illness trajectories, and uncover the underlying mechanisms driving chronic symptoms.

    This research has the potential to transform how complex conditions are diagnosed, understood, and treated - bringing us closer to predictive diagnostics and targeted therapies for patients.

    Learn More About the MAESTRO Study

  • Funded and In Progress.

    CODA is a proud funding partner of Sequence ME and Long Covid, the world's largest long-read, whole-genome sequencing study of any disease. Led by Action for ME in partnership with the University of Edinburgh and Oxford Nanopore Technologies, this study will analyze the complete genetic code of 9,000 people with ME and 9,000 people with Long Covid to identify rare and structural genetic changes that may underlie these conditions.

    Learn More About Sequence ME & Long COVID

  • Funded and Completed.

    CODA partnered with Chronicle Bio and PrecisionLife to launch the MELO Study, focused on identifying biomarkers linked to Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. These insights help uncover underlying biology, risk factors, and symptom drivers, highlighting key areas for deeper investigation.

    Returning results to participants was a core priority, offering meaningful insight into the research process and the impact of patient participation. This work has the potential to advance targeted studies, improve diagnostics, and accelerate the development of effective treatments.

    Learn More About the Melo Study

Multiple Neuroimmune Programs and Studies are Underway and Seeking Funding.

Subtyping Studies Reveal Distinct Patient Profiles to Drive Targeted Research

  • Seeking Funding.

    CODA CCD investigates altered neuroimmune signaling at the craniocervical junction contributes to the initiation and progression of complex disorders. Structural factors in this region may heighten these neuroimmune shifts. This initiative offers a unique human model for studying and understanding CODA’s five core research areas.

    Learn More About CODA CCD

  • The MIT MAESTRO Study, led by the Tal Research Group at Massachusetts Institute of Technology, is one of the most comprehensive clinical efforts to understand why some individuals recover from infection while others develop chronic illness.

    By collecting biological, cognitive, and physiological data across conditions like Lyme disease and Long COVID, the study aims to identify biomarkers, map illness trajectories, and uncover the underlying mechanisms driving chronic symptoms.

    This research has the potential to transform how complex conditions are diagnosed, understood, and treated - bringing us closer to predictive diagnostics and targeted therapies for patients.

    Learn More About the MAESTRO Study

  • Funded and In Progress.

    CODA is a proud funding partner of Sequence ME and Long Covid, the world's largest long-read, whole-genome sequencing study of any disease. Led by Action for ME in partnership with the University of Edinburgh and Oxford Nanopore Technologies, this study will analyze the complete genetic code of 9,000 people with ME and 9,000 people with Long Covid to identify rare and structural genetic changes that may underlie these conditions.

    Learn More About Sequence ME & Long COVID

  • Funded and Completed.

    CODA partnered with Chronicle Bio and PrecisionLife to launch the MELO Study, focused on identifying biomarkers linked to Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. These insights help uncover underlying biology, risk factors, and symptom drivers, highlighting key areas for deeper investigation.

    Returning results to participants was a core priority, offering meaningful insight into the research process and the impact of patient participation. This work has the potential to advance targeted studies, improve diagnostics, and accelerate the development of effective treatments.

    Learn More About the Melo Study

Multiple Neuroimmune Programs and Studies are Underway and Seeking Funding.

Subtyping Studies Reveal Distinct Patient Profiles to Drive Targeted Research

CODA Craniocervical Dysfunction (CCD) Initiative

 Seeking Funding.

CODA CCD investigates altered neuroimmune signaling at the craniocervical junction contributes to the initiation and progression of complex disorders. Structural factors in this region may heighten these neuroimmune shifts. This initiative offers a unique human model for studying and understanding CODA’s five core research areas.

Learn More About CODA CCD

MAESTRO Study with MIT

The MIT MAESTRO Study, led by the Tal Research Group at Massachusetts Institute of Technology, is one of the most comprehensive clinical efforts to understand why some individuals recover from infection while others develop chronic illness.

By collecting biological, cognitive, and physiological data across conditions like Lyme disease and Long COVID, the study aims to identify biomarkers, map illness trajectories, and uncover the underlying mechanisms driving chronic symptoms.

This research has the potential to transform how complex conditions are diagnosed, understood, and treated - bringing us closer to predictive diagnostics and targeted therapies for patients.

Learn More About the MAESTRO Study

Sequence ME & Long COVID

Funded and In Progress.

CODA is a proud funding partner of Sequence ME and Long Covid, the world's largest long-read, whole-genome sequencing study of any disease. Led by Action for ME in partnership with the University of Edinburgh and Oxford Nanopore Technologies, this study will analyze the complete genetic code of 9,000 people with ME and 9,000 people with Long Covid to identify rare and structural genetic changes that may underlie these conditions.

Learn More About Sequence ME & Long COVID

MELO Study

Funded and Completed.

CODA partnered with Chronicle Bio and PrecisionLife to launch the MELO Study, focused on identifying biomarkers linked to Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. These insights help uncover underlying biology, risk factors, and symptom drivers, highlighting key areas for deeper investigation.

Returning results to participants was a core priority, offering meaningful insight into the research process and the impact of patient participation. This work has the potential to advance targeted studies, improve diagnostics, and accelerate the development of effective treatments.

Learn More About the MELO Study

CODA Fellowships

Breakthroughs happen when the best minds work together. Advancing this field requires bringing leading scientific labs into the work and creating real incentives for collaboration. Supporting fellows is one of the most effective ways to attract top talent, expand expertise, and keep research centered on the needs of patients.

CODA supports junior and senior fellows at leading medical institutions to ensure science remains centered on patients.


To inquire, please email info@complexdisorders.org.

CODA Fellowships

Breakthroughs happen when the best minds work together. Advancing this field requires bringing leading scientific labs into the work and creating real incentives for collaboration. Supporting fellows is one of the most effective ways to attract top talent, expand expertise, and keep research centered on the needs of patients.

CODA supports junior and senior fellows at leading medical institutions to ensure science remains centered on patients.


To inquire, please email info@complexdisorders.org.

A scientist wearing safety glasses and gloves working with laboratory equipment in a lab.

Data/AI and Multiomics Studies

CODA invests in multiomics studies and AI data analysis to have the data and tools to better understand which patients respond to which therapies: the backbone of precision medicine. Therapies only succeed when we understand who may respond and why. CODA subtyping studies investigate biological differences across patients to better understand who may respond to specific treatments. 

Medical team including two women and one man gathered around a large screen displaying a detailed X-ray of a human head, with a woman in a lab coat pointing at the X-ray using a marker.

CODA Fellowships

Breakthroughs happen when the best minds work together. Advancing this field requires bringing leading scientific labs into the work and creating real incentives for collaboration. Supporting fellows is one of the most effective ways to attract top talent, expand expertise, and keep research centered on the needs of patients.

CODA supports junior and senior fellows at leading medical institutions to ensure science remains centered on patients.


To inquire, please email info@complexdisorders.org.

A woman with curly hair and glasses in a lab coat working on a laptop in a laboratory setting, with a person working at a computer in the background.

General Neuroimmune Science Study Inquiries

CODA consistently accepts proposals that examine the most important areas of neuroimmune science. 

To inquire, please email info@complexdisorders.org.

CODA Publications

Reproducibility of genetic risk factors identified for long COVID using combinatorial analysis across US and UK patient cohorts with diverse ancestries

Published: 08 May 2025

Read More